Molecular and Tumor Immunology Laboratory

The Laboratory of Molecular and Tumor Immunology, led by Bernard A. Fox, Ph.D., has both a preclinical effort to develop new strategies to increase therapeutic potential, and a clinical effort to translate new findings into better therapies for patients with cancer. The lab has investigated the use of protein array technology and microaffinity proteomics to assess IgG responses against the spectrum of possible cancer antigens. They have successfully used this technology to identify vaccine-induced T-cell responses in preclinical models and are exploring this approach in cancer patients enrolled in combination immunotherapy trials. In collaboration with colleagues, they are also working to identify the cancer peptidome, an area of research they believe will provide insights into identifying optimal antigen targets for vaccines. The lab is a leader in the use of tissue-based immunoscore and immunoprofiling to evaluate pretreatment immune responses in preclinical animal models and patients with cancer. Learn more about their research.

Fox and staff in Lab

Team members 

Bernard A. Fox, Ph.D., member and Harder Family Endowed Chair for Cancer Research 
Michael Afentoulis, research associate 
Carmen Ballesteros-Merino, Ph.D., scientist  
Shawn Jensen, Ph.D., scientist  
Tarsem Moudgil, research associate 
Keith Wegman, Ph.D., scientist

Alumni

Ilka Assmann 
Daniel Bethmann, M.D. 
Sarah Church, Ph.D. 
Michael LaCelle 
Yiwei Chu, M.D. 
Annemieke Dols, Ph.D., M.D. 
Zipei Feng, M.D., Ph.D. 
Kevin Friedman, Ph.D. 
David Lashley, M.D. 
Hong-Ming Hu, Ph.D. 
Erik Huntzicker, Ph.D. 
Tyler Hulett, Ph.D. 
Jun Ma, Ph.D. 
Sebastian Marwitz, Ph.D. 
Sybren Meijer, Ph.D., M.D. 

David Messenheimer, Ph.D. 
Michael Neuberger 
John Osterholzer, M.D. 
Christopher Paustian, Ph.D. 
Ulf Petrausch, M.D. 
Christian Poehlein, M.D. 
Sachin Puri, Ph.D. 
Dominik Ruttinger, Ph.D., M.D. 
Philip Sayaharuban 
Petra Schuberth 
James Thompson 
Chris Twitty, Ph.D. 
Reineki van de Ven, Ph.D. 
Hauke Winter, M.D. 
Jane Yamada