Michael J. Gough, Ph.D.

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Michael J. Gough, Ph.D.
Associate member, Integrated Therapies Laboratory
Earle A. Chiles Research Institute
Providence Cancer Institute

Adjunct assistant professor, Department of Molecular Microbiology and Immunology, Oregon Health & Science University

Adjunct clinical research assistant professor, Department of Radiation Oncology, Oregon Health & Science University

Dr. Gough’s research is focused on understanding the role of immune cells in the success and failure of conventional cancer therapies. Together with Associate Member Marka R. Crittenden M.D., Ph.D., he leads the Integrated Therapies Laboratory, which is a collaborative effort combining expertise in surgical, medical and radiation oncology to translate hypotheses from preclinical models into more effective cancer treatments. Dr. Gough studies preclinical models to understand the link between therapeutic outcome and the inflammatory biology of cancerous tumors, and to test immunotherapies which may improve outcomes for patients with cancer. In particular, he is investigating the immune consequences of conventional cancer therapy to develop immunotherapies which target and destroy residual microscopic disease. Learn more about Dr. Gough’s research.

Training

Education 

  • Bachelor of Science in human biology and business administration, University of Aston in Birmingham, United Kingdom, 1994
  • Master of Science in immunology, University of Birmingham, United Kingdom, 1995
  • Doctor of Philosophy in tumor immunology, The University of Leeds, United Kingdom, 1999
  • Postdoctoral fellow, laboratory of Dr. Richard Vile, Mayo Clinic, Rochester, Minn., 1999-2004
  • Postdoctoral fellow, laboratory of Dr. Andrew Weinberg, Earle A. Chiles Research Institute, Providence Cancer Institute, Portland, Ore., 2004-2009

Professional Experience

  • Adjunct assistant professor, Department of Molecular Microbiology and Immunology, Oregon Health & Science University, 2013-present
  • Associate member, Integrated Therapies Laboratory, Earle A. Chiles Research Institute, Providence Cancer Institute, 2009-present
  • Adjunct clinical research assistant professor, Department of Radiation Oncology, Oregon Health & Science University, 2006-present

Memberships & Awards

Memberships

  • American Association for Cancer Research
  • American Association of Immunology
  • Chair, Institutional Animal Care and Use Committee, Providence Portland Medical Center 
  • Society for Immunotherapy of Cancer

Honors & Awards

  • Master of Science with distinction, Department of Immunology, University of Birmingham, 1995
  • First class honors, human biology and business administration, University of Aston, Birmingham, 1994

Publications

Gough MJ, Baird JR, Bell RB. Implantable biomaterials to provide local immunotherapy following surgical resection. Oncotarget. 2018;9(102):37612-3. PMID: 30701017; PMC6340878.

Tang ES, Newell PH, Wolf RF, Hansen PD, Cottam B, Ballesteros-Merino C, Gough MJ. Association of Immunologic Markers With Survival in Upfront Resectable Pancreatic Cancer. JAMA Surg. 2018. PMID: 30090929.

Baird JR, Bell RB, Troesch V, Friedman DJ, Bambina S, Kramer G, Blair T, Medler TR, Wu Y, Sun Z, de Gruijl TD, van de Ven R, Leidner R, Crittenden MR, Gough MJ. Evaluation of explant responses to STING ligands: personalized immunosurgical therapy for head and neck squamous cell carcinoma. Cancer Res. 2018. PMID: 30224374.

Crittenden MR, Zebertavage L, Kramer G, Bambina S, Friedman D, Troesch V, Blair T, Baird JR, Alice A, Gough MJ. Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity. Sci Rep. 2018;8(1):7012. PMID: 29725089; PMC5934473. 

Tormoen GW, Crittenden MR, Gough MJ. Role of the immunosuppressive microenvironment in immunotherapy. Adv Radiat Oncol. 2018;3(4):520-6. PMID: 30370351; PMC6200899.

Bell RB, Gough MJ, Seung SK, Jutric Z, Weinberg AD, Fox BA, Crittenden MR, Leidner RS, Curti B. Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy. Oral Oncol. 2016;61:166-76. PMID: 27614589.

View Dr. Gough’s full list of peer-reviewed publications