Providence Cancer Institute Franz Dysplasia Clinic focuses on people who have or are at high risk for anal dysplasia. This is a spectrum of disease that ranges from low-grade lesions, such as anogenital condyloma and low-grade precancers, to high-grade precancerous lesions with potential to progress into invasive anal cancer.
Precancerous lesions, and nearly 90 percent of anal cancers, are due to chronic infection with oncogenic strains of human papillomavirus. Simple screenings allow for earlier detection of precancerous changes caused by HPV. We effectively screen for and treat anal dysplasia, with the aim of preventing it from progressing into anal cancer.
We provide a comprehensive combination of cytology and office-based procedures. These approaches are shown to eliminate high-grade dysplasia lesions in up to 80 percent of patients and to reduce the number of lesions that progress into cancer.
- Anal Pap smear screening
- High-resolution anoscopy (magnified examination of the anal canal with biopsy of abnormal lesions)
- Targeted treatment of dysplastic lesions using infrared coagulation (a light-based ablative therapy)
- Topically based treatment options
- Information about HPV and HPV vaccination
- Patient education and support for anal health
- Patient access to integrative medicine and psychosocial support
- Smoking cessation and nutrition resources
- Training for health care providers who wish to perform anal Pap smear screenings in their own offices
Who should be screened?
- Persons who have a history of genital HPV infection, condyloma or previous anal cancer
- Persons living with HIV or AIDS
- Persons who have chronic anal irritation, growths, and/or lesions that bleed
- Men who have sex with men
- Persons who have a history of receptive anal intercourse
- Women with a history of cervical, vaginal or vulvar dysplasia or cancer
- Solid-organ transplant recipients or others with chronically suppressed immune systems
The Providence Dysplasia Clinic team draws on the expertise of:
- Colon and rectal surgeons
- Medical oncologists
- Cancer researchers
- Oncology nurses and nurse practitioners