Monoclonal gammopathy of undetermined significance
Also known as:
Monoclonal gammopathy of undetermined significance, called MGUS, is a condition which involves the immune arm of the body white blood cells. These immune cells are called plasma cells.
White blood cells fight infections in the body. When people have MGUS, their bone marrow makes too many of the plasma cells. These white blood cells make a protein called monoclonal protein (M-protein).
MGUS itself is a benign disorder, causes no symptoms, and–in most cases–does not lead to any problems. But in some people, MGUS can turn into a serious condition. One serious condition is multiple myeloma, which is a cancer of the white blood cells involved in MGUS. That is why it must be monitored.
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