PCRC_C140503

A Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small (<=2 cm) Peripheral Non-Small Cell Lung Cancer

This randomized phase III trial is studying different types of surgery to compare how well they work in treating patients with stage IA non-small cell lung cancer.

Key Eligibility:

• Suspected or proven Non-Small Cell Lung Cancer (NSCLC), meeting both preoperative and intraoperative criteria: Preoperative criteria, Peripheral lung nodule greater than or equal to 2 cm by CT scan. Center of the tumor must be located in the outer third of the lung in either the transverse, coronal, or sagittal plan. Tumor location must be suitable for either lobar or sublobar resection (wedge resection or segmentectomy). No pure ground opacities or pathologically confirmed N1 or N2 disease.

Intraoperative criteria: Histologically confirmed NSCLC. Confirmation of N0 status by frozen section examination of nodal levels 4, 7, and 10 on the right side and 5, 6, 7, and 10 on the left side* Levels 4 and 7 nodes may be sampled by mediastinoscopy or at the time of thoracotomy or video-assisted thoracoscopic surgery (VATS) exploration* [Note: *Nodes previously sampled by mediastinoscopy either immediately prior to or within 6 weeks of the definitive surgical procedure (thoracotomy or VATS) do not need to be resampled]

• No evidence of locally advanced or metastatic disease
Phase III
NCT00499330
Oncology
Lung
Alison Conlin, M.D.
CALGB
Brenda Fisher

The Pacific Cancer Research Consortium clinical trials are offered at multiple locations throughout Oregon, Washington, Alaska, California, and Idaho. To find a location near you, please contact the Patient Engagement Center at 844-552-2734.