Phase IB Study of a Galectin Inhibitor (GR-MD-02) and Pembrolizumab in Patients with Metastatic Melanoma
This study is a dose escalation of GR-MD-02 with the standard therapeutic dose of pembrolizumab in patients with advanced melanoma.
* Patients with metastatic or unresectable melanoma for whom treatment with pembrolizumab is indicated. Histological confirmation of melanoma will be required by previous biopsy or cytology.
* Patients who have radiographic progression using Response Evaluation Criteria In Solid Tumors (RECIST) currently on pembrolizumab are also eligible.
* Patients with active autoimmune disease except for autoimmune thyroiditis or vitiligo.
* Patients with history of colitis.
* Patients with untreated brain metastases. Patients with treated brain metastases who demonstrate control of brain metastases with follow-up imaging 4 or more weeks after initial therapy are eligible.
Brendan Curti, M.D.
Earle A Chiles Research Institute (EACRI)
- Oncology and Hematology Care Eastside